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Trio Fam - Majum

Majumdar start his career as a Poster Illustrator to Film Technician. His early films were credited to Yatrik (phonetically Jatrik in Bengali). Yatrik was the screenname of the trio of directors Tarun Majumdar, Sachin Mukherji, and Dilip Mukherji until 1963 after which each began to be credited separately. As Yatrik, their first venture was Chaowa Paowa (1959) starring Uttam Kumar and Suchitra Sen.[12] Yatrik made Kancher Swarga (1962) featuring Dilip Mukherjee in the lead.

Trio Fam - Majum

The Masters of Indian MusicAt their NYC debut collaboration, a trio of acclaimed artists share their passion for traditional Indian classical music. Grammy Award-nominated sitar master, composer, conductor and educator Gaurav Mazumdar is a member of the illustrious Mazumdar family and was a student of the legendary maestro Ravi Shankar. After four decades of study and performing, Rupak Kulkarni has established himself as one of the preeminent bansuri masters and an exponent of the maihar gharana, having studied with Hariprasad Chaurasia from the age of 12. Hindole Majumdar is one of the most accomplished tabla players of his generation. He received his first formal training at the age of 5 and continues to study with the great tabla maestro Sankha Chatterjee.

To test the hypothesis that multiple candidate loci contribute to disease and eliminate gene coverage biases in our 53 previously identified candidate genes, we performed Nimblegen targeted re-sequencing for 153 patients from our initial whole-exome sequencing cohort in a trio design which included 82 affected individuals and 71 unaffected family members (Fig 1). We achieved an average coverage of 71.4x and 99% of the target exons were covered at 20x. Principal component analysis of our candidate genes against the ExAC dataset revealed that several genes including MYH6, KMT2D, EP300 and EP400 show an enrichment of rare private mutations despite their high intolerance to common mutations (RVIS: MYH6 = -2.78, KMT2D = -5.29) in the ExAC cohort. This is also reflected by an enrichment of rare benign mutations in these intrinsically variable genes (S7 Fig) based on ClinVar annotation. Despite the significant reduction of benign mutations by applying stringent allele filtering thresholds (p = 0.021; Fisher exact test), it remains a challenging task to discriminate between causative and non-causative missense mutations in common and often asymptomatic diseases of the aortic valve, such as BAV. For this reason, we used the recently developed Combined Annotation Dependent Depletion (CADD) framework to characterize and rank co-segregating mutations in our candidate genes [22]. This framework provides a genome-wide estimate of protein altering mutations and can be used as a meta-annotation tool to rank variants according to their pathogenicity scores. Based on the unbiased CADD score statistics, we observed a significant (p20 and ranking among the top 1% most pathogenic mutations genome-wide (p 0.05, chi-square, Fig 5b). These results are consistent with the notion that natural selection removes rare protein altering mutations from the general population and implies that only a small but highly pathogenic fraction of familial transmitted mutations contributes to disease in our cohort.

To assess whether highly ranked pathogenic mutations are enriched in disease relevant gene sets, we compared their pathogenic burden for 50 hallmark gene sets in patients and controls using the Wilcoxon rank sum statistic. We found a significant enrichment of CADD scores in members of the Notch signaling and the previously highlighted myogenesis gene sets (p 20. Finally, by ranking mutations based on their predicted pathogenicity we were able to exclude mutations in intrinsically variable genes and identified the small but highly pathogenic fraction of transmitted missense mutations that are likely to contribute to CHD in 12 families of our 51 families (S3 Table). Notably, our highest ranked disease-segregating mutations clustered predominantly in genes along the Notch signaling axis (Table 2). We identified two families with mutations in MAML1, a transcriptional co-activator of NOTCH1 involved in outflow tract defects [42,43]. Both rare mutations with CADD scores > 20 (c.G2129A:p.R710Q; c.G913A:p.A305T) segregated with aortic valve disease in five affected patients in both families, including a distantly related cousin. In addition, a family trio with a private mutation (c.G1540A:p.G959A) in JARID2 was identified which segregated with bicuspid aortic valve in the index case and his father. JARID2 has been reported to cause outflow tract malformations in a mouse model and regulates NOTCH1 expression via histone modifications in the developing heart [44]. This is in line with the identification of a patient with an overlapping phenotype and a compound heterozygous mutation (maternal: c.C3830T:p.P1277L/paternal: T4211G:p.V1404G) in the Notch signaling repressor SMARCA4 (BRG1). This analysis is however insufficient to conclusively assess novel gene associations with CHD based on family association alone, especially in the light of emerging evidence supporting a role of deleterious mutations inherited from unaffected family members [45].

Platforms for sharing genomic and phenotype data have been developed to promote genomic research, while maximizing the utility of existing datasets and minimizing the burden on participants. The value of genomic analysis of trios or family members has increased, especially in rare diseases and cancers. This article aims to argue the necessity of protection when sharing data from both patients and family members.

Farm to Table Dinner$115/person or $200 coupleThis is one of the best dinner experiences you will ever have. You dine here at the farm and depending on the weather, time of year, and other things going on here at the farm, your dinning experience can be held inside the greenhouses, outside right on the farm or inside our building.Upon arrival you will be greeted with cocktiails and hor'devourses followed by a guided tour of the farm. After the tour you will be shown to your seats for a candle lite dinner of a 6 course meal which is all prepared from farm grown foods and by the farm ladies and sometimes by local chefs.First course is fresh made and baked breads served with assorted homemade fruit butters and infused oils for dipping. Second course is our own homemade potatoe soup with a piece of battered and deep fried bacon. Next comes our famous farm salad of all fresh hydroponically grown greens and tomatoes with our broccoli and cauliflower, sweet organic carrots topped with our Florida fresh avocados and our strawberries with our own poppyseed dressing and crumbled goat cheese. The next course is an appetizer of stuffed acorn squash served with a stuffed tulip tomatoe. Main course will then be served consisting of bacon wrapped tenderloin stuffed with sweet apricots with a bourbon apple glaze served with wild rice and white asparagus seasoned to perfection. Dessert will end the evening....and our dessert will be a trio of chocolate zucchini cake, our famous strawberry dessert and our very own homemade cheesecake topped with fresh berries. Wine is paired with each course, including dessert, but coffee is served after dessert.

In 1993 Trilok toured his own trio in support of the album THE CRAZY SAINTS, which featured not only Joe Zawinul but also Pat Metheny. Audiences were enthralled by his compositions that linked subtle Indian rhythms and Indian singing with elements of modern jazz and rock. The following year the band was expanded to a quartet and touring extended to include a US coast-tocoast tour and 40+ European shows. 041b061a72


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